A new study published in the journal Southeastern Naturalist is the first to document that American alligators (Alligator mississippiensis) on the Atlantic...
According to a new theory proposed by University of Edinburgh Professor Arjun Berera and colleagues, shortly after the Universe came into existence it...
A Yale University-led study suggests that abrupt shifts in climate caused by massive volcanic eruptions helped to trigger poorly understood revolts —...
University of Sussex researcher Yutaka Tokuda and co-authors have applied electrical charges to manipulate liquid metal into 2D shapes such as letters...
An international team of paleontologists from the United States, Sweden, and Japan has retrieved original pigment, beta-keratin and muscle proteins from...
Origin of Universe’s heavy elements, ranging from gold to uranium, has finally been confirmed, after a gravitational wave source was seen and heard for...
For the first time, astronomers have observed the source of gravitational waves, created by the merger of two neutron stars. The cataclysmic aftermaths...
Chalmers University of Technology Professor Erik Kristiansson and co-authors have identified over 70 new metallo-β-lactamase genes that make bacteria...
Archaeologists digging in the City of David, the Old City of Jerusalem, have found dozens of ancient clay seals, also known as bullae.
A bulla of ‘Achiav...
A jaw-dropping new image from the NASA/ESA Hubble Space Telescope captures what appears to be a strange galaxy with two ‘tails,’ but is actually the...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
Analysis of science data from Cassini’s final plunge is ongoing, but NASA researchers already have a clear understanding of how the spacecraft behaved...
Saturn’s hazy moon has surprisingly extreme rainstorms, according to new research published in the journal Nature Geoscience.
It’s raining on Titan....
An international team of researchers from Canada and China has sequenced the genome of the economically important species Apostichopus japonicus, commonly...
A research team led by Princeton University astrophysicists has discovered a co-moving pair of bright Sun-like stars, HD 240430 and HD 240429, with a significant...
A new study of ancient DNA appears to rule out the likelihood that inhabitants of Easter Island intermixed with Native South Americans prior to the arrival...
A new study in the Astronomical Journal finds that giant exoplanets with long-period orbits are more likely to be found around young stars that have a...
A team of researchers from Switzerland and the Netherlands has rediscovered and deciphered a 95-foot (29 m) long Luwian inscription found in the late 19th...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
