African coelacanths (Latimeria chalumnae) reach maturity around the age of 55 and gestate their offspring for 5 years, according to a study published in...
In a new study, astronomers used data from the NASA/ESA Hubble Space Telescope to calculate a more accurate distance to an ultra-diffuse galaxy called...
The sweat bee Megalopta genalis, a Neotropical nocturnal bee species that navigates under the forest canopy at light intensities 10 times dimmer than starlight,...
Betelgeuse, which is located roughly 724 light-years away in the constellation of Orion, is the second-closest red supergiant to Earth. From November 2019...
Artificial lighting was a crucial physical resource for expanding complex social and economic behavior in groups of Paleolithic humans. Furthermore, the...
Using the Atacama Large Millimeter/submillimeter Array (ALMA), astronomers have detected a galactic-scale supermassive black hole-driven wind in HSC J124353.93+010038.5...
Xanthohumol, a prenylated flavonoid produced by hops (Humulus lupulus), and its synthetic derivative, tetrahydroxanthohumol, can mitigate the diet-induced...
An international team of astronomers from the United States and the United Kingdom has made the discovery of a giant, almost symmetrical arc of galaxies...
The two ancient obsidian flakes recovered from a now submerged archaeological site beneath Lake Huron represent the oldest and farthest east confirmed...
Cosmic filaments are cylindrical tendrils of matter hundreds of millions of light-years across. In new research, published in the journal Nature Astronomy,...
In 2020, paleontologists described an ancient species, Oculudentavis khaungraae, based on a tiny skull trapped in a piece of Cretaceous-period amber from...
Astronomers using NASA’s Interstellar Boundary Explorer (IBEX) satellite have mapped the boundary of the heliosphere, the vast region of space surrounding...
Dendrohyrax interfluvialis lives in the wet and dry forests that lie between the two rivers in coastal regions of southeastern Ghana, southern Togo and...
A team of researchers from Thomas Jefferson University, Philadelphia, the University of Southern California, the Beckman Research Institute of the City...
Ornithologists have discovered a new species of berrypecker (genus Melanocharis) in cloud forest in the Kumawa Mountains of western New Guinea (West Papua...
A team of archaeologists from the Israel Antiquities Authority (IAA) has found an unbroken chicken egg in an Islamic-period cesspit at the archaeological...
![Ternary structure of Polθ on a DNA/RNA primer-template: (A) Polθ polymerase; (B) DNA/RNA extension by Polθ and PolθΔL; (C) structure of Polθ:DNA/RNA:ddGTP; (D) superposition of Polθ:DNA/RNA (marine) and Polθ:DNA/DNA (orange, 4x0q); the fingers and thumb subdomains undergo reconfiguration; (E) superposition of Polθ:DNA/RNA (marine) and Polθ:DNA/DNA (orange, 4x0q) highlighting a 12-Å shift of K2181 (blue box; thumb) and a 4.4-Å shift of E2246 (gray box; palm); (F) superposition of nucleic acids and ddGTP from Polθ:DNA/RNA:ddGTP and Polθ:DNA/DNA:ddGTP structures; (G) top: electron density of ddGTP and 3′ primer terminus in Polθ:DNA/RNA structure; bottom: zoomed-in image of the superposition of active sites, illustrating a different conformation of ddGTP in the Polθ:DNA/RNA (blue) and Polθ:DNA/DNA (salmon) complexes; (H) interactions between ribose 2’-hydroxyl groups of the RNA template and residues in the Polθ:DNA/RNA structure; red dashed lines, hydrogen bonds; (I) DNA/RNA used for cocrystallization with Polθ and ddGTP (top); strong electron density is present for four base pairs [nucleotides located at positions 2 to 5 (underlined) of the DNA/RNA] and two base pairs resulting from an incorporated ddGMP (2’,3’ dideoxyguanosine monophosphate) (green; position 1) and a bound unincorporated ddGTP (red; position 0) in the active site (top); interactions between Polθ and nucleic acids in Polθ:DNA/RNA:ddGTP (bottom); interactions between residues and phosphate backbone, sugar oxygen, or nucleobase are shown in blue, yellow, and green, respectively; hydrogen bonds between Polθ and ribose 2’-hydroxyl groups are indicated (boxed residues); (J) interactions between Polθ and nucleic acids in Polθ:DNA/DNA:ddGTP (4x0q); color scheme identical to (I). Image credit: Chandramouly et al., doi: 10.1126/sciadv.abf1771.](https://cdn.sci.news/images/2021/06/image_9759-Polymerase-Theta-195x110.jpg)
