An international group of scientists from Japan and Australia has identified two essential genes involved in the regulation of rapid eye movement (REM) sleep. The acetylcholine pathway has been proposed to be important for wakefulness and REM sleep, but genetic evidence has been missing. Using a knockout of acetylcholine receptor genes, Niwa et al show that Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an undetectable level and...
