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Marco Onorati et al. describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and Zika virus (ZIKV)-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, and a ZIKV-infected micrencephalic brain, the team shows that ZIKV infects both neocortical and spinal NES cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death. ZIKV infection of NES cells and RGCs causes centrosomal depletion and mitochondrial sequestration of phospho-TBK1 during mitosis. The scientists also found that nucleoside analogs inhibit ZIKV replication in NES cells, protecting them from ZIKV-induced pTBK1 relocalization and cell death. They established a model system of human neural stem cells to reveal cellular and molecular mechanisms underlying neurodevelopmental defects associated with ZIKV infection and its potential treatment. Image credit: Marco Onorati et al.

Researchers Discover How Zika Virus Causes Fetal Brain Damage

Aug 25, 2016 by News Staff

According to a team of researchers led by Yale University, infection by the Zika virus diverts a key protein necessary for neural cell division in the...

Honey is considered an added sugar. Image credit: Estel Heitz.

American Heart Association: Children Should Consume Less Than 25 Grams of Added Sugars Daily

Aug 23, 2016 by News Staff

Children ages 2 to 18 should eat or drink less than six teaspoons of added sugars daily (equivalent to about 100 calories or 25 grams), according to new...

This electron micrograph shows clumps of methicillin-resistant Staphylococcus aureus. Image credit: Janice Haney Carr / Jeff Hageman / USCDCP.

Researchers Discover New Way to Attack Staphylococcus aureus

Aug 17, 2016 by News Staff

A team of researchers at Imperial College London (ICL), UK, has found a ‘salty way’ to attack Staphylococcus aureus, an important opportunistic human...

Close-up of North America: parts of the southern U.S., including parts of Florida, Texas and Louisiana, are vulnerable to transmission of Zika virus. Image credit: Abdallah M. Samy et al.

New Map Predicts Spread of Zika Virus

Aug 16, 2016 by Enrico de Lazaro

An international group of scientists led by the University of Kansas has created a detailed map that shows areas of the world most likely to see cases...

Liver showing accumulation of bilirubin pigment. Image credit: Department of Pathology, Calicut Medical College / CC BY-SA 4.0.

Bilirubin Contributes to Suppression of Immune Response after Islet Transplants

Aug 12, 2016 by News Staff

A research team led by Dr. Christopher Adin from College of Veterinary Medicine at North Carolina State University has found that doses of bilirubin, a...

An ‘out of body experience’ could help people suffering from chronic pain.

‘Out of Body Experience’ Can Tackle Chronic Pain, Research Shows

Aug 11, 2016 by News Staff

A new study published in the European Journal of Pain shows that inducing a virtual ‘out of body experience’ can significantly reduce the intensity...

Image of the external morphology of a hominin foot bone (Paranthropus robustus or Homo ergaster) shows the extent of expansion of the primary bone cancer beyond the surface of the bone. Image credit: Patrick Randolph-Quinney.

South African Fossils Reveal Earliest Hominin Evidence of Cancer

Jul 29, 2016 by News Staff

A team of paleontologists led by Dr. Patrick Randolph-Quinney from the University of the Witwatersrand (Wits University) in Johannesburg, South Africa,...

Aedes aegypti biting human. Image credit: James Gathany / CDC.

First Confirmed Transmission of Zika Virus by Aedes aegypti Mosquitoes

Jul 26, 2016 by News Staff

Led by University of Texas Medical Branch researcher Prof. Scott Weaver, an international team of scientists is the first to directly connect Aedes aegypti...

Human pap smear showing Chlamydia trachomatis in the vacuoles at 500x. Image credit: Lance Liotta Laboratory.

Scientists Develop First Widely Protective Vaccine against Chlamydia

Jul 22, 2016 by News Staff

A team of scientists in Canada has developed the first widely protective vaccine against chlamydia, a common sexual transmitted infection. Human pap smear...

Human Vaccine for Zika Virus May Have Potential

Jul 19, 2016 by Rafid Rahman

Transmission electron micrograph of Zika virus, which is a member of the family Flaviviridae. Virus particles are 40 nm in diameter, with an outer envelope,...

Escherichia coli. Image credit: Janice Haney Carr / CDC.

Second Case in the US of Bacteria with Colistin Resistance Gene

Jul 14, 2016 by Enrico de Lazaro

For the second time, a clinical strain of Escherichia coli with the colistin resistance gene mcr-1 has been detected in humans in the United States, according...

In AD, changes in tau protein lead to the disintegration of microtubules in brain cells. Image credit: Alzheimer’s Disease Education and Referral Center / National Institute on Aging.

Progress in Development of First Vaccine for Alzheimer’s Disease

Jul 13, 2016 by News Staff

An international team of researchers from the United States and Australia has made a successful vaccine formulation that targets pathological proteins...

This false-color image shows Escherichia coli. Image credit: Geralt.

Pan-Drug Resistant ‘Superbug’ Found in US

Jul 1, 2016 by Rafid Rahman

This false-color image shows Escherichia coli. Image credit: Geralt. ‘Superbug’ bacteria affect two million people and kill at least 23,000 Americans...

The inoculation of viruses into mosquito bite sites is an important and common stage of arbovirus infections. Dr. McKimmie and his colleagues show that inflammation at bite sites aids viral replication and dissemination in vivo, resulting in more severe infection. These findings define additional targets for post-exposure prophylactic intervention. Image credit: Marieke Pingen et al.

Inflammation from Mosquito Bites May Enhance Virus Replication, Dissemination

Jun 22, 2016 by News Staff

According to a mouse study published this week in the journal Immunity, the swelling and irritation that make mosquito bites so unpleasant may provide...

Drinking piping hot coffee, tea and yerba mate probably causes cancer of the esophagus, scientists say. Image credit: Wild0ne.

Very Hot Coffee, Tea, Mate May Increase Risk of Cancer of Esophagus

Jun 20, 2016 by News Staff

Beverages surpassing 149 degrees Fahrenheit (65 degrees Celsius) may increase the risk of tumors in the esophagus, which resides in the chest area below...

Parkinson’s disease. Image credit: Blausen Gallery 2014 / Wikiversity Journal of Medicine, doi: 10.15347/wjm/2014.010.

Stem Cell Transplants Promote Recovery in Non-Human Primate Model of Parkinson’s Disease

Jun 8, 2016 by News Staff

A team of scientists has found that grafting human parthenogenetic stem cell-derived neural stem cells (hpNSCs) into non-human primates modeled with Parkinson’s...

Illustration depicting angina. Image credit: Blausen Gallery 2014 / Wikiversity Journal of Medicine, doi: 10.15347/wjm/2014.010.

Stem Cell Therapy Reduced Angina Frequency for ‘No-Option’ Patients

Jun 1, 2016 by News Staff

A two-year clinical study with over 160 patients with refractory angina (chronic symptomatic coronary artery disease) randomized to low and high dose CD34+...

Jumping Frenchmen of Maine, a rare disorder characterized by an unusually extreme startle reaction, is similar to Latah. It was first identified during the 19th century in Maine and Quebec among an isolated population of lumberjacks of French Canadian descent. This image shows a group of lumberjacks who have just downed a giant sequoia (California, 1905). Image credit: Library of Congress, Washington, DC.

Culture-Bound Syndromes: Entire Disease Category Your Doctor May Be Missing

May 23, 2016 by Rafid Rahman

Jumping Frenchmen of Maine, a rare disorder characterized by an unusually extreme startle reaction, is similar to Latah. It was first identified during...

Scientists at Tel Aviv University, Israel, and Tulane University in New Orleans say obesity and osteoporosis should not be treated separately (University of Massachusetts Lowell)

Neurotensin: Scientists Identify New Biomarker for High-Fat-Diet-Induced Obesity

May 13, 2016 by News Staff

Researchers have identified a potential new biological marker for the development of obesity, according to a study published online May 11, 2016 in the...