A small dose of glucose can improve memory in older adults, motivate them to work harder and puts them in a good mood when performing difficult tasks,...
Senescent cells increase in many tissues with aging and are often associated with inflammation, tissue damage, and age-related diseases. Senolytics are...
Transfer of vital genetic information within a cell isn’t the one-way telegraph, according to a new study published in the journal Cell Metabolism.
The...
In search of a way to rejuvenate the immune system of older adults, a team of scientists from the University of Arizona College of Medicine and elsewhere...
Activation of the immune system by the Escherichia coli infection may temporarily disrupt formation of long-term memories in older rats by reducing levels...
Individuals with affective problems (depression and anxiety) are at an increased risk of a greater decline in cognitive state, according to a review of...
Intestinal stem cells are responsible for maintaining the lining of the intestine, which typically renews itself every 5 days. When an injury or infection...
According to a new study, published in the American Heart Association journal Hypertension, older adults who take a mitochondrial-targeted antioxidant...
Reproductive stem cells of male fruit flies (Drosophila melanogaster) use a genetic trick to stay perpetually young across generations, according to new...
Scientists have revealed that senescent naked mole rat cells downregulate key metabolic processes and are more resistant to DNA damage than their mouse...
Exercise training may delay the decline in cognitive function that occurs in individuals who are at risk of or have Alzheimer’s disease, with aerobic...
According to a new study published in the journal Circulation, proper exercise can reverse damage to sedentary, aging hearts and help prevent risk of future...
The lifespans of flies and worms are prolonged by inhibiting the activity of RNA polymerase III, an enzyme common to all animals, finds a new study published...
A rare loss-of-function mutation in a gene called SERPINE1 identified among Old Order Amish in Indiana is associated with a longer lifespan, improved metabolism...
A team of researchers from the Universities of Exeter, Brighton and Oxford has rejuvenated senescent cells to be functionally younger. This discovery builds...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
In a study in mice, a research team at Albert Einstein College of Medicine has found that stem cells in the hypothalamus, a region of the brain that controls...
A recent study led by University of Illinois researchers found that middle-aged adults with higher levels of lutein — a nutrient found in green leafy...
Researchers at the Salk Institute for Biological Studies have found further evidence that fisetin, a natural flavonoid found in strawberries and other...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
