Exercise training may delay the decline in cognitive function that occurs in individuals who are at risk of or have Alzheimer’s disease, with aerobic...
According to a new study published in the journal Circulation, proper exercise can reverse damage to sedentary, aging hearts and help prevent risk of future...
The lifespans of flies and worms are prolonged by inhibiting the activity of RNA polymerase III, an enzyme common to all animals, finds a new study published...
A rare loss-of-function mutation in a gene called SERPINE1 identified among Old Order Amish in Indiana is associated with a longer lifespan, improved metabolism...
A team of researchers from the Universities of Exeter, Brighton and Oxford has rejuvenated senescent cells to be functionally younger. This discovery builds...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
In a study in mice, a research team at Albert Einstein College of Medicine has found that stem cells in the hypothalamus, a region of the brain that controls...
A recent study led by University of Illinois researchers found that middle-aged adults with higher levels of lutein — a nutrient found in green leafy...
Researchers at the Salk Institute for Biological Studies have found further evidence that fisetin, a natural flavonoid found in strawberries and other...
According to a study published recently in the Journals of Gerontology: Medical Sciences, drinking a beetroot juice before exercise makes the brain of...
A duo of researchers at Columbia University has identified two genes (TMEM106B and GRN) that greatly impact normal brain aging, starting at around age...
A new animal study published in the journal Cell Reports shows vitamin D engages longevity genes to increase lifespan and prevent the accumulation of toxic...
A new study in rats led by Dr. Beth Allison of the University of Cambridge, UK, suggests that the aging clock begins ticking even before we are born and...
Individuals who speak two or more languages, even those who acquired the second language in adulthood, may slow down cognitive decline from aging, according...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
