Fasting affects peripheral circadian clocks in the liver and skeletal muscle, causing them to rewire their metabolism, which can ultimately lead to improved health and protection against aging-associated diseases, according to a new study published in the journal Cell Reports.
Kinouchi et al reveal that fasting affects peripheral circadian clocks in the liver and skeletal muscle. Fasting operates by influencing the circadian clock and fasting-sensitive transcription factors, thereby cooperatively achieving fasting-specific temporal gene regulation. Image credit: Kinouchi et al, doi: 10.1016/j.celrep.2018.11.077.
The circadian clock operates within the body and its organs as intrinsic time-keeping machinery to preserve homeostasis in response to the changing environment.
And, while food is known to influence clocks in peripheral tissues, it was unclear, until now, how the lack of food influences clock function and ultimately affects the body.
“We discovered fasting influences the circadian clock and fasting-driven cellular responses, which together work to achieve fasting-specific temporal gene regulation,” said University of California Irvine’s Professor Paolo Sassone-Corsi, senior author of the study.
“Skeletal muscle, for example, appears to be twice as responsive to fasting as the liver.”
The study was conducted using mice, which were subjected to 24-hour periods of fasting.
While fasting, the researchers noted the animals exhibited a reduction in oxygen consumption, respiratory exchange ratio, and energy expenditure, all of which were completely abolished by refeeding, which parallels results observed in humans.
“The reorganization of gene regulation by fasting could prime the genome to a more permissive state to anticipate upcoming food intake and thereby drive a new rhythmic cycle of gene expression,” Professor Sassone-Corsi said.
“In other words, fasting is able to essentially reprogram a variety of cellular responses.”
“Therefore, optimal fasting in a timed manner would be strategic to positively affect cellular functions and ultimately benefiting health and protecting against aging-associated diseases.”
The research opens new avenues of investigation that could ultimately lead to the development of nutritional strategies to improve health in humans.
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Kenichiro Kinouchi et al. Fasting Imparts a Switch to Alternative Daily Pathways in Liver and Muscle. Cell Reports 25 (12): 3299-3314; doi: 10.1016/j.celrep.2018.11.077
