Tag Archive for 'Epigallocatechin gallate'

A concentration of 2.5 μM EGCG and ECG enhanced health- and lifespan as well as stress resistance in Caenorhabditis elegans. Catechins hampered mitochondrial respiration in Caenorhabditis elegans after 6-12 hrs and the activity of complex I in isolated rodent mitochondria. The impaired mitochondrial respiration was accompanied by a transient drop in ATP production and a temporary increase in ROS levels in Caenorhabditis elegans. After 24 hrs, mitochondrial respiration and ATP levels got restored, and ROS levels even dropped below control conditions. The lifespan increases induced by EGCG and ECG were dependent on AAK-2/AMPK and SIR-2.1/SIRT1, as well as on PMK-1/p38 MAPK, SKN-1/NRF2, and DAF-16/FOXO. Long-term effects included significantly diminished fat content and enhanced SOD and CAT activities, required for the positive impact of catechins on lifespan. Image credit: Tian et al., doi: 10.18632/aging.203597.

Study: Green Tea Catechins Extend Health- and Lifespan, Reduce Fat Content in Model Organism

Oct 27, 2021 by Enrico de Lazaro

Green tea is one of the most widely consumed beverages worldwide. Green tea catechins are associated with a delay in aging. In experiments performed in...

An activation of the vascular and neuronal KCNQ5 potassium channel contributes significantly to vasodilation by both green and black tea; the tea polyphenols ECG and EGCG are major contributors to this effect, via hyperpolarization of the voltage dependence of KCNQ5 activation; ECG and EGCG or optimized derivatives of these compounds are candidates for future anti-hypertensive drug development. Image credit: Sci-News.com.

Two Tea Compounds Found to Relax Blood Vessels

Mar 10, 2021 by News Staff

A team of researchers from the University of California, Irvine and the University of Copenhagen has found that two polyphenol compounds found in green...

Zhao et al. provide insights into the mechanisms for EGCG’s anticancer activity and identifies p53 N-terminal domain as a target for cancer drug discovery through dynamic interactions with small molecules. Image credit: Sci-News.com.

Green Tea Compound Stabilizes ‘Guardian of the Genome’ Protein

Feb 17, 2021 by News Staff

Epigallocatechin-3-gallate (EGCG), a polyphenol found in the leaves of green tea (Camellia sinensis), may increase levels of the natural anti-cancer protein...

Flavanols are a large group of flavonoids, which include catechin, epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. They are found in teas, cocoa, fava beans, red wine, and many fruits, particularly in the skins of grapes, apples, and blueberries. Image credit: Marijana.

Flavanol-Rich Diet Could Help Lower Blood Pressure

Oct 22, 2020 by News Staff

Consuming a high-flavanol diet was associated with a significantly lower systolic and diastolic blood pressure and was inversely associated with blood...

Green Tea Polyphenol Active against Tuberculosis Bacteria

Dec 30, 2019 by Enrico de Lazaro

Epigallocatechin gallate (EGCG), one of the principle polyphenolic compounds found in the leaves of the green tea plant (Camellia sinensis), is effective...

The green tea (Camellia sinensis). Image credit: Wilerson S. Andrade / CC BY-SA 2.0.

Green Tea Polyphenol Helps Therapeutic RNAs Slip Inside Cells

Oct 19, 2018 by News Staff

Epigallocatechin gallate (EGCG) is the major polyphenol in the leaves of green tea (Camellia sinensis). This compound is the subject of increasing research...

Green Tea Compound Could Be Key to Preventing Mortality from Heart Attacks, Strokes Caused by Atherosclerosis

Jun 12, 2018 by News Staff

A group of researchers from Emory University in the United States and Lancaster University and the University of Leeds, both in the UK, has discovered...

According to Kathrin Andrich et al, the Epigallocatechin gallate -- a compound found in green tea leaves -- may be of particular benefit to patients struggling with multiple myeloma and amyloidosis. Image credit: Ascyrafft Adnan.

Green Tea Compound Could Have Lifesaving Potential for Patients with Amyloidosis, Multiple Myeloma

Feb 7, 2017 by News Staff

The green-tea polyphenol Epigallocatechin gallate (EGCG) may be of particular benefit to patients struggling with amyloidosis and multiple myeloma, according...