Grapes contain polyphenols and flavonoids that are known for their antioxidative and anti-inflammatory effects.
Grape consumption reduces fatty liver,...
A team of researchers from the University of California, Berkeley, and elsewhere has sequenced and analyzed the genomes of 88 Pacific Ocean rockfish species...
A team of U.S. researchers has found an inverse association between fruit and vegetable intake and mortality in two large prospective cohorts, the Nurses’...
A team of researchers from the United Kingdom and Canada has sequenced the genome of the white-faced capuchin (Cebus imitator), a medium-sized New World...
A gene called AHL15 (AT-hook motif nuclear-localized protein 15) promotes longevity in annual flowering plants, according to a new study published in the...
People with higher optimism are more likely to live longer and to achieve ‘exceptional longevity,’ that is, living to the age of 85 or beyond, according...
A team of scientists from the United States and Brazil has successfully sequenced the genome of the turquoise-fronted Amazon parrot (Amazona aestiva) and...
A team of researchers from Yale University, the University of Oviedo in Spain, the Galapagos Conservancy, and the Galapagos National Park Service has sequenced...
A new study, published in the journal Cell Reports, shows improvements in overall health and brain health, as well as learning and memory in lab mice that...
A new study led by the National Institute on Aging shows that a long daily period of fasting improves the health and survival of male mice, regardless...
Living a healthy lifestyle — eating a healthy diet, exercising regularly, keeping a healthy body weight, not drinking too much alcohol, and not smoking...
Reproductive stem cells of male fruit flies (Drosophila melanogaster) use a genetic trick to stay perpetually young across generations, according to new...
The lifespans of flies and worms are prolonged by inhibiting the activity of RNA polymerase III, an enzyme common to all animals, finds a new study published...
A rare loss-of-function mutation in a gene called SERPINE1 identified among Old Order Amish in Indiana is associated with a longer lifespan, improved metabolism...
A team of researchers from the Universities of Exeter, Brighton and Oxford has rejuvenated senescent cells to be functionally younger. This discovery builds...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
An international team of researchers from the United States and Italy has identified new genetic variants associated with extreme survival and reduced...
A new animal study published in the journal Cell Reports shows vitamin D engages longevity genes to increase lifespan and prevent the accumulation of toxic...
U.S. genetic researchers led by Dr Stuart Kim of Stanford University have sequenced the genomes of 17 supercentenarians to see if they could uncover the...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
