In a scientific first, a research team led by Gladstone Institutes scientists turned mouse skin cells into so-called induced pluripotent stem cells by...
According to a new study published in the journal Nature Neuroscience, a high-salt diet reduces resting blood flow to the brain and causes dementia in...
A process using pluripotent stem cells from mice can generate skin tissue complete with hair follicles, according to a team of researchers from the Indiana...
Vasopressin, also called antidiuretic hormone, is released from the brain, and known to work in the kidney, suppressing a process called diuresis. According...
A specific group of amino acids called branched-chain amino acids (BCAAs) is elevated in the blood of obese, insulin-resistant humans and rodents. A new...
Dementia is an umbrella term used to describe severe changes in the brain that cause memory loss. The condition affects 30-50% of the American population...
A diet that makes one individual lean and healthy might have the complete opposite effect on another, according to a new study published in the journal...
Vanillin, one of the most widely used flavoring products worldwide, is an effective bioactive compound against psoriatic skin inflammation, according to...
A team of scientists led by Dr. Masanobu Komatsu of Sanford Burnham Prebys Medical Discovery Institute has identified a signaling pathway that is essential...
An international team of researchers has found that in both mice and humans, a high-salt diet shrinks the population of a type of gut bacteria called Lactobacillus;...
A bone-derived hormone called osteocalcin is known to affect how we metabolize sugar and fat. In a new study, Professor Mathieu Ferron of the Université...
In a new study published in the journal eLife, Dr. Andrew Cowburn of the University of Cambridge and co-authors show that skin helps regulate blood pressure...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
In a study in mice, a team of researchers at the University of California, Los Angeles, has found that black tea alters energy metabolism in the liver...
An antibody that protects against dengue virus is also effective against Zika in mice, according to a new study published in the journal Nature Immunology.
This...
A research team led by Boston University scientists has identified a new type of lung cell that is implicated in the body’s immune defense against pneumonia-causing...
In a study in mice, a research team at Albert Einstein College of Medicine has found that stem cells in the hypothalamus, a region of the brain that controls...
In a research article published in the journal Scientific Reports, Ohio State University scientists report that male mice fed a diet of 10% tomato powder...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
