A bone-derived hormone called osteocalcin is known to affect how we metabolize sugar and fat. In a new study, Professor Mathieu Ferron of the Université...
In a new study published in the journal eLife, Dr. Andrew Cowburn of the University of Cambridge and co-authors show that skin helps regulate blood pressure...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
In a study in mice, a team of researchers at the University of California, Los Angeles, has found that black tea alters energy metabolism in the liver...
An antibody that protects against dengue virus is also effective against Zika in mice, according to a new study published in the journal Nature Immunology.
This...
A research team led by Boston University scientists has identified a new type of lung cell that is implicated in the body’s immune defense against pneumonia-causing...
In a study in mice, a research team at Albert Einstein College of Medicine has found that stem cells in the hypothalamus, a region of the brain that controls...
In a research article published in the journal Scientific Reports, Ohio State University scientists report that male mice fed a diet of 10% tomato powder...
Researchers at the Salk Institute for Biological Studies have found further evidence that fisetin, a natural flavonoid found in strawberries and other...
In a study published this week in the Annals of Clinical and Translational Neurology, researchers from Temple University and the Sapienza University of...
An international team of scientists from the United States and Japan has seen how a particular gene, called the fatty acid binding protein 7 (FABP7), is...
Vitamin B3, also known as niacin and nicotinic acid, prevents eye degeneration in glaucoma-prone mice, according to a study published in the Feb. 17 issue...
A team of researchers at Northwestern University has discovered a type of retinal ganglion cell that may cause myopia when it dysfunctions. The study is...
In the Jan. 10 issue of the journal Stem Cell Reports, Dr. Michiko Mandai and colleagues at the RIKEN Center for Developmental Biology in Japan report...
As many as 33% of autism cases could be explained by a scarcity of a protein called nSR100 in the brain, a new study in the journal Molecular Cell has...
A new study in mice shows that dopamine neuron activity plays a key role in judgment of time, slowing down the internal clock.
Sofia Soares et al investigated...
According to Dr. Joe Tsien, a neuroscientist at the Medical College of Georgia at Augusta University, the brain’s basic computational algorithm is organized...
According to a new study published in the journal Frontiers in Behavioral Neuroscience, ultrasonic vocal communication in adult mice is affected by the...
A research team led by Vanderbilt University Medical Center scientist Prof. James Crowe, Jr., has isolated a human monoclonal antibody that in a mouse...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
