A revolutionary new technique combines a rapid 3D microscopy technique known as lattice light-sheet microscopy with expansion microscopy for nanoscale imaging of fruit fly (Drosophila melanogaster) and mouse neuronal circuits and their molecular constituents that’s roughly 1,000 times faster than other methods. ExLLSM (expansion/lattice light-sheet microscopy) images neural structures with molecular contrast over millimeter-scale volumes, including...