Tag Archive for 'Type I interferon'

Diet-induced obesity results in Paneth cell dysfunction in humans and mice. Image credit: Liu et al., doi: 10.1016/j.chom.2021.04.004.

Western Diet Causes Damage to Immune Cells in Gut, Study Shows

May 19, 2021 by News Staff

Paneth cells, immune cells in the gastrointestinal epithelia, modulate innate immunity and infection. In Crohn’s disease, genetic mutations together...

Bradley et al identify lung stroma as the target of microbiota-driven signals that set the interferon signature in these cells; antibiotic treatment reduces gut microbiota and the lung stromal interferon signature and facilitates early influenza virus replication in lung epithelia, effects that can be reversed by fecal transplantation. Image credit: Bradley et al, doi: 10.1016/j.celrep.2019.05.105.

Study: Gut Bacteria Stimulate Antiviral Signals in Lung Cells to Protect against Flu Virus

Jul 8, 2019 by News Staff

In a study of mice, an international team of scientists has discovered that signals from gut bacteria help to maintain a first line of defense in the lining...