Precise radiocarbon dating indicates that Panagrolaimus kolymaensis, a species of soil nematode new to science, remained in cryptobiosis for about 46,000...
New research shows how the nematode Caenorhabditis elegans, a long-used model organism, can use electric fields to ‘jump’ across Petri plates or onto...
University of California, Santa Barbara’s professors Philip Lubin and Joel Rothman and their colleagues contemplate launching small cryptobiotic lifeforms...
Green tea is one of the most widely consumed beverages worldwide. Green tea catechins are associated with a delay in aging. In experiments performed in...
Post-reproductive Caenorhabditis elegans nematode mothers exhibit a form of primitive lactation, releasing yolk milk through their vulva that can enhance...
A new study in Caenorhabditis elegans worms has identified 14 new genes that promote obesity and 3 genes that prevent diet-induced obesity.
Ke et al. report...
An international group of scientists from the University of Liverpool and the University of Washington Department of Medicine has identified a novel compound...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
A research team led by Scripps Research Institute scientist Dr. Supriya Srinivasan has identified a brain hormone that appears to trigger fat burning in...
Scientists have discovered a new type of photoreceptor protein that is about 50 times more efficient at capturing light than the rhodopsin, a protein that...
An international team of scientists from the United States and China has found a sensor for the reactive molecules linked to diabetic complications. The...
A new animal study published in the journal Cell Reports shows vitamin D engages longevity genes to increase lifespan and prevent the accumulation of toxic...
A group of scientists, led by Dr Jon Pierce-Shimomura of the University of Texas at Austin, has identified a magnetosensitive neuron in the brain of Caenorhabditis...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
