Tag Archive for 'IgA'

Wei et al developed a biomimetic self-propelling micromotor formulation for use as an oral antivirulence vaccine; the propulsion is provided by a magnesium-based core, and a biomimetic cell membrane coating is used to detain and neutralize a toxic antigenic payload; the resulting motor toxoids leverage their propulsion properties in order to more effectively elicit mucosal immune responses. Image credit: Wei et al, doi: 10.1021/acs.nanolett.8b05051.

Self-Propelling Micromotors Deliver Oral Vaccines

Feb 11, 2019 by News Staff

A team of scientists at the University of California San Diego has developed oral antivirulence vaccines powered by self-propelling micromotors that target...

Plasma cells (PC) are found in the central nervous system of multiple sclerosis patients, yet their source and role in multiple sclerosis remains unclear. Rojas et al find that some PC in the central nervous system of mice with experimental autoimmune encephalomyelitis (EAE) originate in the gut and produce immunoglobulin A (IgA). Moreover, the researchers show that IgA + PC are dramatically reduced in the gut during EAE, and likewise, a reduction in IgA-bound fecal bacteria is seen in multiple sclerosis patients during disease relapse. Image credit: Rojas et al, doi: 10.1016/j.cell.2018.11.035.

Gut-Derived Immune Cells Reduce Brain Inflammation in Multiple Sclerosis

Jan 8, 2019 by News Staff

Studying mice and samples from multiple sclerosis patients, a research team led by University of Toronto scientists found that gut-derived immunoglobulin-A-(IgA)...