Tag Archive for 'Micromotor'

Wei et al developed a biomimetic self-propelling micromotor formulation for use as an oral antivirulence vaccine; the propulsion is provided by a magnesium-based core, and a biomimetic cell membrane coating is used to detain and neutralize a toxic antigenic payload; the resulting motor toxoids leverage their propulsion properties in order to more effectively elicit mucosal immune responses. Image credit: Wei et al, doi: 10.1021/acs.nanolett.8b05051.

Self-Propelling Micromotors Deliver Oral Vaccines

Feb 11, 2019 by News Staff

A team of scientists at the University of California San Diego has developed oral antivirulence vaccines powered by self-propelling micromotors that target...

Karshalev et al created a micromotor pill and demonstrated its attractive use as a platform for oral delivery of active micromotors: (A) left: schematic of in vivo administration of a micromotor pill for actuation in the stomach; right: schematic of the micromotor pill composition consisting of a lactose/maltose pill matrix and the encapsulated a magnesium/titanium dioxide/polylactic-co-glycolic acid (Mg/TiO2/PLGA) micromotors; a zoom-in view illustrates the micromotor structure consisting of a Mg microsphere core with a TiO2 shell layer and a cargo-loaded PLGA film coating; (B) schematic of micromotor pill dissolution in gastric fluid and subsequent micromotor release; (C) left: image showing different sizes of disk-shaped micromotor pills; center: microscope image showing the dissolution of a micromotor pill in gastric fluid simulant; right: propulsion of the released Mg-based micromotors in gastric fluid simulant. Image credit: Karshalev et al, doi: 10.1021/acsnano.8b03760.

Researchers Create Micromotor Pill

Sep 14, 2018 by News Staff

A team of scientists at the University of California, San Diego has found a way to encapsulate micromotors into pills. The pill’s coating protects the...