A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
A biocompatible and highly elastic hydrogel sealant can effectively seal wounds in shape-shifting tissues without the need for common staples or sutures,...
Archaeologists have found a well-preserved Early Bronze Age wooden vessel in the Swiss Alps. The artifact could help researchers shed new light on the...
A mysterious hominin species mated with the ancestors of modern-day Sub-Saharan Africans, according to an analysis of modern human genomes published this...
A group of researchers at the Feinstein Institute for Medical Research has identified a protein called Blimp-1 as a likely primary cause of the adverse...
Ancient, independent inactivations of the ucp1 gene, which encodes the uncoupling protein 1, or UCP1 (essential for thermogenesis in brown fat), were a...
After decades of research aiming to understand how DNA is organized in our cells, a team of researchers from the Gladstone Institutes, the Massachusetts...
A team of scientists at the University of Texas Southwestern Medical Center has identified the cells that directly give rise to hair as well as the mechanism...
An international team of scientists has identified a long-sought protein that causes liver fibrosis (scarring), paving the way for new treatments. The...
In a study published recently in the journal PLOS Biology, neuroscientists identified three gut bacteria species — Acetobacter pomorum, Lactobacillus...
The International Barley Genome Sequencing Consortium, which is led by Dr. Nils Stein of the Leibniz Institute of Plant Genetics and Crop Plant Research,...
According to a new study, physical activity can lower the risk of myocardial damage in middle-aged and older adults and reduce the levels of myocardial...
An international team of scientists from the United States and Japan has seen how a particular gene, called the fatty acid binding protein 7 (FABP7), is...
The green-tea polyphenol Epigallocatechin gallate (EGCG) may be of particular benefit to patients struggling with amyloidosis and multiple myeloma, according...
A team of researchers at the University of Warwick, UK, has identified Connexin26 (Cx26) as a key molecule that reacts to carbon dioxide (CO2) in our bodies...
About 8% of the human genome is composed of endogenous retroviruses. According to a new study published in the journal Cell Reports, these retroviruses...
A team of scientists at Michigan State University has discovered that a potential new drug, called CCG-203971, reduces the spread of melanoma cells by...
A team of scientists at the University of California, San Francisco, has discovered a way to inactivate the CRISPR-Cas9 gene-editing system using newly...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
