The so-called i-motifs are knot-like DNA structures formed in the nuclei of human cells and believed to provide critical genomic regulation. In new research, scientists from the Garvan Institute of Medical Research and elswhere used immunoprecipitation and next-generation sequencing to identify i-motif structures in human DNA. Peña Martinez et al. observed a total of 53,000 i-motifs among three human cells lines: MCF7, U2OS, HEK293T. Image credit:...
