Tag Archive for 'Induced pluripotent stem cell'

Choanoflagellate Sox can induce pluripotency in mammalian cells. Image credit: Gao et al., doi: 10.1038/s41467-024-54152-x.

Researchers Recreate Mouse from Choanoflagellate Gene that Predates Animals

Nov 19, 2024 by News Staff

Scientists from Queen Mary University of London and the University of Hong Kong have created mouse stem cells capable of generating a fully developed mouse...

When mesenchymal stem/stromal cells (MSCs) age, the transcription factor GATA6 is increasingly produced in the cell to induce aging response; by transcription factor-based cellular reprogramming, aged MSCs are rejuvenated with a reduction in GATA6 effects on cellular aging. Image credit: AlphaMed Press.

Scientists Identify Gene Responsible for Aging of Human Cells

Dec 1, 2020 by News Staff

A gene called GATA6 (GATA binding protein 6) regulates aging of human mesenchymal stem/stromal cells (MSCs), according to new research from the University...

Liu et al demonstrate that induced pluripotency can be achieved through targeted activation of endogenous Oct4 or Sox2 genes. With CRISPR activation, the promoter and enhancer are specifically remodeled, Oct4 or Sox2 is derepressed in fibroblasts, and reprogramming is triggered toward pluripotency. Image credit: Liu et al, doi: 10.1016/j.stem.2017.12.001.

Scientists Create First Stem Cells Using CRISPR Technology

Jan 20, 2018 by News Staff

In a scientific first, a research team led by Gladstone Institutes scientists turned mouse skin cells into so-called induced pluripotent stem cells by...

3D observation of contact between host bipolar cells (green) and graft photoreceptors (red). Image credit: RIKEN.

Stem Cell-Based Transplantation Approach Improves Vision in End-Stage Retinal-Degeneration Mice

Jan 12, 2017 by News Staff

In the Jan. 10 issue of the journal Stem Cell Reports, Dr. Michiko Mandai and colleagues at the RIKEN Center for Developmental Biology in Japan report...