A team of marine biologists from Monterey Bay Aquarium and the California Academy of Sciences has discovered and described a new species of the butterflyfish...
An Ohio State University-led study is the first to show how couples spend time minute-by-minute. Published in the journal Sex Roles, the findings will...
A study published in the journal Plasma Sources Science and Technology argues that Mars, with its 96% carbon dioxide (CO2) atmosphere, has nearly ideal...
Planetary researchers with NASA’s Cassini mission have detected a cloud of toxic hybrid ice high above the south pole of Saturn’s hazy moon, Titan.
This...
In a paper published this week in the journal Nature, the BASE collaboration at CERN reports the most precise measurement ever made of the magnetic moment...
A new study published in the journal Advances in Space Research suggests that solar storms create a complex electrical environment around Phobos, giving...
A new study published in the journal Southeastern Naturalist is the first to document that American alligators (Alligator mississippiensis) on the Atlantic...
According to a new theory proposed by University of Edinburgh Professor Arjun Berera and colleagues, shortly after the Universe came into existence it...
A Yale University-led study suggests that abrupt shifts in climate caused by massive volcanic eruptions helped to trigger poorly understood revolts —...
University of Sussex researcher Yutaka Tokuda and co-authors have applied electrical charges to manipulate liquid metal into 2D shapes such as letters...
An international team of paleontologists from the United States, Sweden, and Japan has retrieved original pigment, beta-keratin and muscle proteins from...
Origin of Universe’s heavy elements, ranging from gold to uranium, has finally been confirmed, after a gravitational wave source was seen and heard for...
For the first time, astronomers have observed the source of gravitational waves, created by the merger of two neutron stars. The cataclysmic aftermaths...
Chalmers University of Technology Professor Erik Kristiansson and co-authors have identified over 70 new metallo-β-lactamase genes that make bacteria...
Archaeologists digging in the City of David, the Old City of Jerusalem, have found dozens of ancient clay seals, also known as bullae.
A bulla of ‘Achiav...
A jaw-dropping new image from the NASA/ESA Hubble Space Telescope captures what appears to be a strange galaxy with two ‘tails,’ but is actually the...
A team of researchers led by Case Western Reserve University School of Medicine has discovered a conserved molecular pathway that controls lifespan and...
Astronomers using data from the NASA Kepler spacecraft’s reborn K2 mission have discovered a planetary system containing at least three exoplanets, orbiting...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
