Tag Archive for 'Cryo-electron microscopy' | Sci.News

Cryo-EM structure of the remdesivir and RNA bound RdRp complex: (A and B) two views of cryo-EM map (A) and structure (B) of the nsp12-nsp7-nsp8 in complex with template-primer RNA and remdesivir; (C) surface view of the RdRp active site with the electrostatic potential from red (negative) to blue (positive); for clarity, residues 410-442, 834-919 of nsp12 and nsp8 are excluded from the figure; the covalently bound remdesivir in the monophosphate form and the product, pyrophosphate, are shown; the active site is emphasized with a yellow dashed circle; the template groove, the entrance for NTP and the elongation direction are annotated with different colored arrows; (D) a close view of the RdRp active site, showing the covalently bound RMP, pyrophosphate, and magnesium ions; key residues and bases that interact with remdesivir are shown; (E and F) superposition of the conserved RdRp motifs (A to G) of the RNA bound complex with the apo structure colored in gray, with a close view at the active site (E) and at the exit of the template and primer strand (F). Image credit: Yi et al, doi: 10.1126/science.abc1560.

Study Sheds New Light on Remdesivir’s Mechanism of Action against SARS-CoV-2

May 4, 2020 by News Staff

In a paper published in the journal Science, a team of researchers from China reports the structure of the antiviral drug remdesivir bound to both a molecule...