Tag Archive for 'Ecarin' | Sci.News

Schematic overview of the mechanism of action of the implemented snake venom proteins. Ecarin, a procoagulant snake venom protein bypasses the activation of series of clotting factors via intrinsic and extrinsic clotting pathway and directly activates prothrombin to thrombin thereby producing a fibrin blood clot. Once the clot is formed, clot breakdown (fibrinolysis) is initiated by the activation of plasminogen mainly by tissue plasminogen activator (tPA), forming active plasmin which proteolytically acts on the fibrin blood clot. Textilinin, an antifibrinolytic snake venom protein binds to plasmin with high specificity and inhibits the action of plasmin, stabilizing the fibrin blood clot. Image credit: Yegappan et al., doi: 10.1002/adhm.202200574.

Researchers Create Snake Venom Hydrogel that Rapidly Stops Uncontrolled Bleeding

Jun 20, 2022 by News Staff

The newly-developed rapid wound sealant is composed of two snake venom proteins: ecarin, which rapidly initiates blood clotting, and textilinin, which...