Tag Archive for 'Leptin resistance' | Sci.News

Mazor et al showed that, in rodents, obesity induced matrix MMP-2 activation in the hypothalamus. In turn, MMP-2 activation reduced leptin-mediated signaling by promoting leptin receptor degradation. MMP-2 deletion in the hypothalamus increased leptin receptor expression and reduced fat accumulation in mice fed a high-fat diet. Image credit: Mazor et al, doi: 10.1126/scitranslmed.aah6324.

Researchers Discover Destructive Mechanism that Causes ‘Leptin Resistance’ Phenomenon

Aug 24, 2018 by News Staff

Obesity is associated with increased blood concentrations of the anorexigenic hormone leptin; however, obese individuals are resistant to its anorexigenic...