Tag Archive for 'Prion'

The normal form of amyloid beta has been tagged with a yellow marker in these cells, making healthy cells a uniform pale yellow (left). Contact with prion forms of amyloid beta -- for example in extracts from human brain tissue -- forces these yellow proteins into the sticky prion form as well, leading to the formation of bright yellow clumps (right). Image credit: Prusiner Lab / UCSF Institute for Neurodegenerative Diseases.

Alzheimer’s Amyloid-Beta and Tau Proteins Act as Prions, New Research Finds

May 7, 2019 by News Staff

Prions are misfolded versions of a protein that can spread like an infection by forcing normal copies of that protein into the same self-propagating, misfolded...

Thioflavin S positive amyloid plaques in the hippocampus (left) and cortex of lab mice inoculated with the artificial human prion, rhuPrion. Image credit: Kim et al, doi: 10.1038/s41467-018-04584-z.

Scientists Synthesize First Artificial Human Prion

Jun 11, 2018 by News Staff

A team of scientists at Case Western Reserve University School of Medicine has created the first artificial human prion. Thioflavin S positive amyloid...