Tag Archive for 'Remdesivir'

Cryo-EM structure of the remdesivir and RNA bound RdRp complex: (A and B) two views of cryo-EM map (A) and structure (B) of the nsp12-nsp7-nsp8 in complex with template-primer RNA and remdesivir; (C) surface view of the RdRp active site with the electrostatic potential from red (negative) to blue (positive); for clarity, residues 410-442, 834-919 of nsp12 and nsp8 are excluded from the figure; the covalently bound remdesivir in the monophosphate form and the product, pyrophosphate, are shown; the active site is emphasized with a yellow dashed circle; the template groove, the entrance for NTP and the elongation direction are annotated with different colored arrows; (D) a close view of the RdRp active site, showing the covalently bound RMP, pyrophosphate, and magnesium ions; key residues and bases that interact with remdesivir are shown; (E and F) superposition of the conserved RdRp motifs (A to G) of the RNA bound complex with the apo structure colored in gray, with a close view at the active site (E) and at the exit of the template and primer strand (F). Image credit: Yi et al, doi: 10.1126/science.abc1560.

Study Sheds New Light on Remdesivir’s Mechanism of Action against SARS-CoV-2

May 4, 2020 by News Staff

In a paper published in the journal Science, a team of researchers from China reports the structure of the antiviral drug remdesivir bound to both a molecule...

Colorized scanning electron micrograph of a VERO E6 cell (blue) heavily infected with SARS-COV-2 virus particles (orange), isolated from a patient sample. Image credit: NIAID.

Scientists Review Strategies for Combating SARS-CoV-2 and Other Coronaviruses

Apr 24, 2020 by News Staff

In a paper published in the journal Frontiers in Microbiology, a team of researchers at the University of North Carolina at Chapel Hill review possible...

This transmission electron microscope image shows SARS-CoV-2 isolated from a patient in the U.S. Image credit: NIAID-RML.

Remdesivir Has Therapeutic Potential against SARS-CoV-2 Coronavirus, Scientists Say

Apr 1, 2020 by News Staff

Two new papers published in the journal Antimicrobial Agents and Chemotherapy provide a summary of therapeutic compounds that showed potential in fighting...

Colorized transmission electron micrograph of SARS-CoV particles (orange) found near the periphery of an infected cell (green). Image credit: NIAID Integrated Research Facility.

Antiviral Drug Remdesivir Inhibits RNA Polymerase in MERS and SARS Coronaviruses: Study

Feb 27, 2020 by News Staff

Researchers from the University of Alberta and Gilead Sciences, Inc. have discovered that the experimental antiviral drug remdesivir is effective in treating...

de Wit et al show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. This colorized scanning electron micrograph shows MERS virus particles (blue) both budding and attached to the surface of infected VERO E6 cells (yellow). Image credit: NIAID.

Remdesivir: Experimental Antiviral Drug Shows Promise against MERS Virus in Rhesus Macaques

Feb 19, 2020 by News Staff

Middle East respiratory syndrome coronavirus (MERS-CoV) is closely related to the COVID-19 coronavirus (also known as SARS-CoV-2 and 2019-nCoV) that has...