Tag Archive for 'TRIM28' | Sci.News

Brattas et al. report that ERVs are bound by TRIM28 in human neural progenitor cells. This results in the establishment of local heterochromatin that affects nearby gene expression, suggesting a role for ERVs in the control of transcriptional networks in the developing human brain. Interestingly, ERVs bound by TRIM28 are mostly enriched for elements that integrated around 35–55 million years ago, thus not binding to the most recent ERVs as well as ancient elements. Image credit: Per Ludvik Brattas et al, doi: 10.1016/j.celrep.2016.12.010.

Study: Endogenous Retroviruses in Genome Important for Human Brain

Jan 13, 2017 by Enrico de Lazaro

About 8% of the human genome is composed of endogenous retroviruses. According to a new study published in the journal Cell Reports, these retroviruses...