Tag Archive for 'Leptin'

In two large population-based cohorts, Ochoa-Rosales et al. observed longitudinal associations between higher habitual coffee consumption and lower risk of type 2 diabetes and insulin resistance. Image credit: Sci.News.

Coffee Consumption Reduces Risk of Type 2 Diabetes, New Study Suggests

Mar 24, 2023 by Enrico de Lazaro

Coffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes, but underlying mechanisms...

Perry et al provide evidence for stimulation of a glucocorticoid-AgRP neuron axis that promotes food intake and suggest that AgRP neurons may be an attractive therapeutic target to suppress hyperphagia under conditions of leptin deficiency or glucocorticoid excess including Cushing’s disease. Image credit: N.R. Voss / CC BY-SA 3.0.

Study Provides New Insights into Biology of ‘Satiety Hormone’ Leptin

Jun 18, 2019 by News Staff

Leptin, a hormone secreted by fat cells, informs the brain about sufficiency of fuel stores. When insufficient, leptin levels fall, triggering increases...

Mazor et al showed that, in rodents, obesity induced matrix MMP-2 activation in the hypothalamus. In turn, MMP-2 activation reduced leptin-mediated signaling by promoting leptin receptor degradation. MMP-2 deletion in the hypothalamus increased leptin receptor expression and reduced fat accumulation in mice fed a high-fat diet. Image credit: Mazor et al, doi: 10.1126/scitranslmed.aah6324.

Researchers Discover Destructive Mechanism that Causes ‘Leptin Resistance’ Phenomenon

Aug 24, 2018 by News Staff

Obesity is associated with increased blood concentrations of the anorexigenic hormone leptin; however, obese individuals are resistant to its anorexigenic...

Falco peregrinus babylonicus. Image credit: John Gould, Birds of Asia, vol. 1, pl. 4.

Scientists Finally Find Elusive Hormone Leptin in Birds

Jun 25, 2014 by News Staff

Researchers have found leptin – a hormone that regulates body fat storage, metabolism and appetite – in the Peregrine falcon (Falco peregrinus),...