Tag Archive for 'Osteoarthritis'

An aqueous-based extract of turmeric (Curcuma longa) was more effective than placebo for knee pain but did not affect knee effusion-synovitis or cartilage composition. Image credit: Marina Pershina / CC0 1.0.

Turmeric Extract Improves Osteoarthritis Knee Pain, Study Says

Oct 5, 2020 by Enrico de Lazaro

In a new study led by the University of Tasmania, an aqueous-based extract of turmeric (Curcuma longa) improved knee pain versus placebo in patients with...

The top image shows a knee joint in a healthy rat (white indicates cartilage); the second image from top shows a joint with grade 2 untreated osteoarthritis; the third image shows a joint with osteoarthritis that has worsened from grade 2 to grade 4 after six weeks of placebo therapy; the bottom image shows a joint with osteoarthritis that improved from grade 2 to grade 1 (mild) after six weeks of combination therapy with αKLOTHO and TGFβR2. Image credit: Salk Institute.

Powerful Combination of Two Experimental Drugs Counteracts Osteoarthritis in Rats

Jan 27, 2020 by News Staff

A research team headed by scientists at the Salk Institute for Biological Studies has discovered that a combination of two molecules, alpha-KLOTHO (αKLOTHO)...

Dunlop et al sought to identify evidence-based thresholds to maintain disability-free status over 4 years among adults with lower extremity joint symptoms. Image credit: Coombesy.

Study: One Hour a Week of Brisk Walking Could Prevent Disability in Older Adults with Arthritis Pain

Apr 4, 2019 by News Staff

According to a study published in the American Journal of Preventive Medicine, just one hour a week of brisk walking staves off disability in older adults...

Pain in osteoarthritis poses a substantial social and economic burden with fewer than 25% of patients having adequate pain control. NGF has emerged as a key driver of pain behavior in murine studies and antibodies to NGF are potent analgesics in human osteoarthritis. Using a novel virus-like particle, von Loga et al created a therapeutic vaccine that reversibly induced antibodies against NGF and abrogated pain behavior in murine osteoarthritis. Image credit: OpenStax / CC BY 4.0.

Novel Vaccine Blocks Osteoarthritis Pain in Mice

Mar 12, 2019 by News Staff

An international team of scientists from the UK, Switzerland and Latvia has developed a virus-like particle vaccine that could be used to treat chronic...

Knee osteoarthritis, also known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage. Image credit: Bruce Blaus / CC BY-SA 4.0.

Menopausal Hormone Therapy Effective against Knee Osteoarthritis: Study

Jan 15, 2019 by News Staff

A new study, published in the journal Menopause, shows that women receiving menopausal hormone therapy had a significantly lower prevalence of symptomatic...

Phenotypes of osteoarthritis: evidence suggests that patients with osteoarthritis fall into multiple phenotypic subgroups defined on the basis of the main driver of disease, one of which is a distinct metabolic phenotype, although all osteoarthritis phenotypes probably involve metabolic alterations; cartilage, bone and synovium are all affected by external and internal drivers of disease such as inflammation, injury or biomechanical alterations, metabolic reprogramming and immunomodulation, but different synovial joint tissues dominate the disease in different patients with osteoarthritis. Image credit: Mobasheri et al / Nature Reviews Rheumatology, doi: 10.1038/nrrheum.2017.50.

Researchers Identify Nine New Genes for Osteoarthritis

Mar 19, 2018 by News Staff

A multinational group of scientists led by the Wellcome Sanger Institute has discovered nine novel genes for osteoarthritis, a degenerative joint disease...

Osteoarthritis Could Be Prevented with Regular Exercise, Good Diet

May 16, 2017 by News Staff

An international team of researchers, led by the University of Surrey, UK, has identified a crucial link between metabolism and osteoarthritis. Phenotypes...

According to Hyldahl et al, running may slow the process that leads to osteoarthritis. Image credit: Skeeze.

Running Lowers Inflammation in Knee Joints, Researchers Say

Dec 12, 2016 by News Staff

Pro-inflammatory molecules actually go down in the knee joint after running, according to a team of researchers at Brigham Young University. According...

Portrait of Anna McNeill Whistler by James Abbott McNeill Whistler, summer 1871.

Scientists Identify Several Genes Associated with Age-Related Conditions

Aug 24, 2016 by News Staff

In an animal study, an international team of researchers led by Medical Research Council (MRC) Harwell Institute scientist Dr. Steve Brown has uncovered...