Tag Archive for 'Adenovirus'

Immunization with ChAd-SARS-CoV-2-S induces both neutralizing antibody and antigen-specific CD8+ T cell responses. While a single intramuscular immunization of ChAd-SARS-CoV-2-S confers protection against SARS-CoV-2 infection and inflammation in the lungs, intranasal delivery of the vaccine induces mucosal immunity, provides superior protection, and possibly promotes sterilizing immunity, at least in mice that transiently or stably express the hACE2 receptor. Image credit: Hassan et al, doi: 10.1016/j.cell.2020.08.026.

Experimental Nasal Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

Aug 27, 2020 by News Staff

A single-dose intranasal vaccine called ChAd-SARS-CoV-2-S prevents SARS-CoV-2 infection in both the upper and lower respiratory tracts of mice, according...

This transmission electron microscope image shows SARS-CoV-2, also known as 2019-nCoV, the virus that causes COVID-19, isolated from a patient in the U.S., emerging from the surface of cells cultured in the lab. Image credit: NIAID-RML.

Chest CT Scans Reliable for COVID-19 Diagnosis, Limited for Identification of Specific Viruses

Mar 5, 2020 by News Staff

Radiologists from Wuhan, China found that chest CT had a low rate of missed diagnosis of COVID-19 (3.9%, 2/51) and may be useful as a standard method for...

The cellular compartment of the tumor microenvironment is made up of tumor cells, immune cells, and stromal cells. Image credit: National Cancer Institute.

Oncolytic Virus Developed that Targets Cancer Cells and Associated Stromal Cells

Nov 26, 2018 by Sam Sander Effron

Researchers from the University of Oxford and PsiOxus Therapeutics have successfully adapted an oncolytic adenovirus that specifically kills cancer cells,...

Brattas et al. report that ERVs are bound by TRIM28 in human neural progenitor cells. This results in the establishment of local heterochromatin that affects nearby gene expression, suggesting a role for ERVs in the control of transcriptional networks in the developing human brain. Interestingly, ERVs bound by TRIM28 are mostly enriched for elements that integrated around 35–55 million years ago, thus not binding to the most recent ERVs as well as ancient elements. Image credit: Per Ludvik Brattas et al, doi: 10.1016/j.celrep.2016.12.010.

Study: Endogenous Retroviruses in Genome Important for Human Brain

Jan 13, 2017 by Enrico de Lazaro

About 8% of the human genome is composed of endogenous retroviruses. According to a new study published in the journal Cell Reports, these retroviruses...

Colorized transmission electron micrograph of adenovirus. Image credit: Dr G. William Gary, Jr. / CDC.

Retooling for Human Gene Therapy: New and Improved Adenoviral Vectors

Aug 20, 2014 by Bhuminder Singh

Dr Juliana Small of the University of Pennsylvania, Drs Raj Kurupati, Xianqyang Zhou and their colleagues from the Wistar Institute have developed a novel...

This colorized scanning electron micrograph shows Mycobacterium tuberculosis, gram-positive bacteria that cause tuberculosis. Image credit: Ray Butler / Centers for Disease Control and Prevention.

Scientists Create New Vaccine against Tuberculosis

Oct 3, 2013 by News Staff

A large group of researchers from Canada has developed a new tuberculosis vaccine based on a genetically modified cold virus. This colorized scanning electron...