Tag Archive for 'FLP-7' | Sci.News

Model depicting the FLP-7/NPR-22 neuroendocrine axis that underlies the 5-HTergic control of body fat loss. In the nervous system, an integrated 5-HT and octopaminergic circuit stimulates body fat loss. In this study, we report the discovery of a tachykinin signalling system that underlies the 5-HTergic control of body fat loss in C. elegans. The FLP-7 neuroendocrine peptide is secreted from the ASI neurons in response to 5-HT and Oct-mediated signalling. The nutrient sensor AAK-2/AMPK acts in the ASI neurons via the CREB co-regulator CRTC-1 to regulate FLP-7 release in response to 5-HT-encoded signals of food availability. Upon release, FLP-7 acts in the intestine via the NPR-22/NK2R receptor to stimulate the ATGL-1 lipase, which drives fat loss. The identification of FLP-7 and NPR-22 addresses a long-standing question about the molecular basis of the central effects of 5-HT on fat loss in peripheral tissues. Image credit: Lavinia Palamiuc et al, doi: 10.1038/ncomms14237.

Scientists Identify Brain-Signaling Molecule that Triggers Fat Burning

Feb 8, 2017 by News Staff

A research team led by Scripps Research Institute scientist Dr. Supriya Srinivasan has identified a brain hormone that appears to trigger fat burning in...