Tag Archive for 'Nodose ganglion' | Sci.News

Borgmann et al. employed intersectional genetic manipulations to probe the feeding and glucoregulatory function of distinct sensory neurons; they reconstructed the gut innervation patterns of numerous molecularly defined vagal and spinal afferents and identified their downstream brain targets; bidirectional chemogenetic manipulations, coupled with behavioral and circuit mapping analysis, demonstrated that gut-innervating, glucagon-like peptide 1 receptor (GLP1R)-expressing vagal afferents relay anorexigenic signals to parabrachial nucleus neurons that control meal termination; moreover, GLP1R vagal afferent activation improved glucose tolerance, and their inhibition elevated blood glucose levels independent of food intake; in contrast, gut-innervating, GPR65-expressing vagal afferent stimulation increased hepatic glucose production and activated parabrachial neurons that control normoglycemia, but they were dispensable for feeding regulation. Image credit: Borgmann et al., doi: 10.1016/j.cmet.2021.05.002.

Gut-Innervating Neurons Can Sense What We Eat, Study Suggests

Jun 7, 2021 by News Staff

In a new study published in the journal Cell Metabolism, researchers took a closer look at the functions of different sensory neurons in the control center...