Tag Archive for 'Organoid'

Formation and characterization of the connected organoids. Image credit: Osaki et al., doi: 10.1038/s41467-024-46787-7.

Neuroscientists Create Human Brain-Mimicking Tissues in Lab

Apr 11, 2024 by News Staff

The idea of growing a functioning human brain-like tissue in a dish has always sounded pretty far-fetched. Towards this goal, researchers at the University...

A hair-bearing skin organoid. Image credit: Indiana University School of Medicine.

Scientists Create Hair-Bearing Human Skin from Pluripotent Stem Cells

Jun 5, 2020 by News Staff

A team of researchers from several U.S. institutions has created an organoid culture system that generates complex skin from human pluripotent stem cells. A...

Transmission electron microscopy analysis of SARS-CoV-2 infected intestinal organoids: (a to h) overview of an intact organoid (a) showing the onset of virus infection (b to d) at different stages of the viral lifecycle, i.e., early double membrane vesicles (DMVs); (e), asterisk, initial viral production in the Golgi apparatus (f and g) and complete occupation of virus particles inside the endomembrane system (h); (i to k) extracellular viruses are observed in the lumen of the organoid (i), and are found at the basal (j) and apical side (k) alongside the microvilli (arrows). Scale bars - 10 μm (a), 2.5 μm (b to d), 250 nm (e), (f), and (h to k) and 100 nm (g). (l to q) Overview of an organoid (l) showing severely infected cells (m and o), disintegrated cells (o) and stressed cells as evident from the atypical nucleoli (p); intact cells reveal DMV areas of viral replication (p), asterisks, and infected Golgi apparatus (q); (r) extracellular clusters of viruses. Scale bars - 10 μm (l), 2.5 μm (m to p) and 250 nm (p to r). Image credit: Lamers et al, doi: 10.1126/science.abc1669.

SARS-CoV-2 Coronavirus Can Infect Gut Enterocytes

May 5, 2020 by News Staff

SARS-CoV-2, a novel coronavirus that causes the COVID-19 disease, can infect enterocytes in the intestine and multiply there, according to a study by researchers...

In cell cultures analyzed in the study, APN01 inhibited the coronavirus load by a factor of 1,000-5,000. Image credit: Tibor Kulcsar / IMBA.

Experimental Drug Blocks Growth of SARS-CoV-2 Coronavirus in Cell Cultures and Organoids

Apr 3, 2020 by News Staff

A trial drug called APN01 or human recombinant soluble ACE2 (hrsACE2) can significantly block early stages of SARS-CoV-2 infections, according to a paper...

Dr. Koehler and co-authors describe a deﬁned in vitro 3D culture system that generates skin organoids from mouse pluripotent stem cells. The skin organoids contain self-organized skin layers and skin appendages, including hair follicles, sebaceous glands, and adipocytes. Image credit: Lee et al, doi: 10.1016/j.celrep.2017.12.007.

Researchers Use Mouse Pluripotent Stem Cells to Grow Hairy Skin

Jan 3, 2018 by News Staff

A process using pluripotent stem cells from mice can generate skin tissue complete with hair follicles, according to a team of researchers from the Indiana...