Tag Archive for 'Epicatechin gallate'

A concentration of 2.5 μM EGCG and ECG enhanced health- and lifespan as well as stress resistance in Caenorhabditis elegans. Catechins hampered mitochondrial respiration in Caenorhabditis elegans after 6-12 hrs and the activity of complex I in isolated rodent mitochondria. The impaired mitochondrial respiration was accompanied by a transient drop in ATP production and a temporary increase in ROS levels in Caenorhabditis elegans. After 24 hrs, mitochondrial respiration and ATP levels got restored, and ROS levels even dropped below control conditions. The lifespan increases induced by EGCG and ECG were dependent on AAK-2/AMPK and SIR-2.1/SIRT1, as well as on PMK-1/p38 MAPK, SKN-1/NRF2, and DAF-16/FOXO. Long-term effects included significantly diminished fat content and enhanced SOD and CAT activities, required for the positive impact of catechins on lifespan. Image credit: Tian et al., doi: 10.18632/aging.203597.

Study: Green Tea Catechins Extend Health- and Lifespan, Reduce Fat Content in Model Organism

Oct 27, 2021 by Enrico de Lazaro

Green tea is one of the most widely consumed beverages worldwide. Green tea catechins are associated with a delay in aging. In experiments performed in...

An activation of the vascular and neuronal KCNQ5 potassium channel contributes significantly to vasodilation by both green and black tea; the tea polyphenols ECG and EGCG are major contributors to this effect, via hyperpolarization of the voltage dependence of KCNQ5 activation; ECG and EGCG or optimized derivatives of these compounds are candidates for future anti-hypertensive drug development. Image credit: Sci-News.com.

Two Tea Compounds Found to Relax Blood Vessels

Mar 10, 2021 by News Staff

A team of researchers from the University of California, Irvine and the University of Copenhagen has found that two polyphenol compounds found in green...

Flavanols are a large group of flavonoids, which include catechin, epicatechin, epigallocatechin, epicatechin gallate and epigallocatechin gallate. They are found in teas, cocoa, fava beans, red wine, and many fruits, particularly in the skins of grapes, apples, and blueberries. Image credit: Marijana.

Flavanol-Rich Diet Could Help Lower Blood Pressure

Oct 22, 2020 by News Staff

Consuming a high-flavanol diet was associated with a significantly lower systolic and diastolic blood pressure and was inversely associated with blood...