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Hirai et al. demonstrated that a high-sucrose diet during adolescence induces psychosis-related behavioral endophenotypes, including hyperactivity, poor working memory, impaired sensory gating, and disrupted interneuron function in mice deficient for GLO1, an enzyme involved in detoxification of sucrose metabolites. Image credit: Tokyo Metropolitan Institute of Medical Science.

High-Sucrose Diet during Adolescence May Contribute to Pathogenesis of Psychiatric Disorders

Dec 28, 2021 by Enrico de Lazaro

Using a mouse model, a team of researchers at the Tokyo Metropolitan Institute of Medical Science demonstrated that high-dietary sucrose consumption during...