Xanthine, which is found in coffee, tea and chocolate, may play a role in the generation of interleukin-17-producing T helper (Th17) cells, an important subtype of cells in the intestine. Duan et al. identified a mechanism of intestinal Th17 cell differentiation that emerges from an intestinal epithelial cell-associated an unfolded protein response. Image credit: Duan et al., doi: 10.1016/j.immuni.2023.02.018. “One of the concepts in our field is...