Tag Archive for 'Oxidative stress'

Regular intake of grapes may improve eye health in older adults, specifically in augmenting MPOD, which can be explained by an increase in plasma total antioxidant capacity and phenolic content, and the downregulation of AGEs. Image credit: Couleur

Study: Regular Grape Consumption May Improve Eye Health in Older Adults

Oct 10, 2023 by News Staff

In a double-blind, randomized, placebo-controlled study of 34 Singapore older adults, consuming grapes — a natural source of antioxidants and other...

A concentration of 2.5 μM EGCG and ECG enhanced health- and lifespan as well as stress resistance in Caenorhabditis elegans. Catechins hampered mitochondrial respiration in Caenorhabditis elegans after 6-12 hrs and the activity of complex I in isolated rodent mitochondria. The impaired mitochondrial respiration was accompanied by a transient drop in ATP production and a temporary increase in ROS levels in Caenorhabditis elegans. After 24 hrs, mitochondrial respiration and ATP levels got restored, and ROS levels even dropped below control conditions. The lifespan increases induced by EGCG and ECG were dependent on AAK-2/AMPK and SIR-2.1/SIRT1, as well as on PMK-1/p38 MAPK, SKN-1/NRF2, and DAF-16/FOXO. Long-term effects included significantly diminished fat content and enhanced SOD and CAT activities, required for the positive impact of catechins on lifespan. Image credit: Tian et al., doi: 10.18632/aging.203597.

Study: Green Tea Catechins Extend Health- and Lifespan, Reduce Fat Content in Model Organism

Oct 27, 2021 by Enrico de Lazaro

Green tea is one of the most widely consumed beverages worldwide. Green tea catechins are associated with a delay in aging. In experiments performed in...