Researchers from the European project ‘Automatic Detection of VAscular Networks for Cancer Evaluation’ (ADVANCE) have developed the world’s first scanner that detects blood vessels grown by a malignant melanoma with an infrared laser beam in 30 seconds. Current skin cancer diagnosis can last a number of weeks and be very upsetting. Multiple stages can involve visiting a GP, being sent to a dermatologist for a skin biopsy, waiting for laboratory...
![KLFs are a subfamily of zinc finger transcriptional regulators with highly characterized roles in proliferation, survival, metabolism, and response to stress. Hsieh et al demonstrate that KLFs are critical determinants of aging, influencing both lifespan and age-related deterioration, and are broadly required for lifespan extension in all four mechanistically distinct longevity models tested. Importantly, the team provides evidence that these effects are mediated by KLF regulation of autophagy (autophagy was assessed using a GFP::LGG-1 translational reporter; GFP-positive puncta [red arrow] were counted in 30-150 total hypodermal seam cells in 10–20 animals) and are conserved in a mammalian system via a functional ortholog, KLF4. Together, the findings provide a role for the KLFs as a transcriptional regulatory point in longevity. Image credit: Hsieh et al, doi: 10.1038/s41467-017-00899-5.](https://cdn.sci.news/images/2017/10/image_5324-Aging-Pathway-195x110.jpg)
